1. Which of these is not a characteristic of tablet formulation by Agglomerative phase of the communication process?
a) Tablets are stronger
b) Usage of more binding agent
c) Rapid dissolution
d) Increase in internal surface area of the granules
Explanation: Agglomerative phase of communication is a recent process which involves grinding the drug in a ball mill for a long time to affect spontaneous agglomeration. The tablets so produced were stronger and showed rapid dissolution in comparison to tablets made by another method. It gave an increased internal surface area of the granules prepared by APOC method.
2. Capsules with bigger particles and intense packing have poor drug release and dissolution rate due to an increase in the pore size.
a) True
b) False
Explanation: Compression force while the making of tablet and packing density (capsule packing) can inhibit or promote dissolution. Capsules with fine particles and intense packing have poor drug release and dissolution due to a decrease in the pore size between the molecules. Thus giving them poor penetrability into the GI fluids.
3. Which one of them is not a common form of excipients of drug manufacturing?
a) Diluents
b) Binders
c) Sweeteners
d) Essential oils
Explanation: Excipients are added to ensure stability, shelf life, functionalibility, uniform composition, etc. Some of the common excipients are diluents, granulating agents, binders, buffers, sweeteners, lubricants, disintegrants, coatings, emulsifier, colorants, complexing agents, surfactants, etc.
4. Vehicles are the solvent system for the liquefied drug. Which one of them is not an example of a kind of vehicle?
a) Aqueous vehicle
b) Non-aqueous water-miscible vehicles
c) Non-aqueous water immiscible vehicles
d) A salt solution of the drug
Explanation: Vehicle is the solvent system for a liquid oral drug. There are 3 types of solvent drug, aqueous vehicle consisting of water, syrup, etc. Non-aqueous water-miscible vehicles consisting of propylene glycol, glycerol, sorbitol, etc. Nonaqueous water immiscible vehicles consisting of vegetable oils
5. Which one of the following will be an example of organic diluents?
a) Starch
b) Dicalcium phosphate
c) Tetracycline
d) Tween 80
Explanation: Tween 80 is a solubilizer. Dicalcium phosphate and tetracycline are inorganic diluents. Starch is organic diluents. Diluents are added to tablets if the required dosage is inadequate to produce necessary bulk
6. What is the function of a granulating agent in drug formulation?
a) Promote cohesive compacts
b) Added if the required dosage is inadequate so that necessary bulk can be produced
c) Tablets can disintegrate easily
d) Used as solubilizer
Explanation: Binders and granulating agents are used to hold powders together to form compact tablets. They help in the formation of granules and promote cohesive compacts for compressible materials. It ensures that the tablet remains intact after compression
7. What is the full form of PVP and what is its function in drug formation?
a) Polyvinyl propylene, diluent
b) Polyvinyl pyrrolidine, solubilizing agent
c) Polyvinyl propylene, buffering agent
d) Polyvinyl pyrrolidine, Binding agent
Explanation: Binding agents are used to holding the powders together to form bigger granules. This helps to ensure the tablet remains intact. PVP is polyvinyl pyrrolidine used as a binding agent in pharmaceutical industries
8. Which one of the following sentences depicts the function of Disintegrants correctly?
a) These agents help in holding the powders together to form granules
b) These agents overcome the cohesive strength of the tablets and help in dissolution
c) These agents help in the flow of granules and reduce friction between particles
d) Added when the required dosage is inadequate
Explanation: Disintegrants are the agents which overcome the cohesive strength and break them when they come in contact with the water. Binders are the agents that help in holding the powders together to form granules. Lubricants help in the flow of granules and reduce friction between particles. Binders are added when required dosage is inadequate
9. A large amount of binders tends to increase the hardness of tablets.
a) True
b) False
Explanation: The proportion of binders in any tablet formulation is very critical. Increase in the amount of binders tends to increase the hardness and decrease the disintegration and dissolution rates of the tablet.
10. An example of lubricants will be __________
a) PVP
b) Carbowaxes
c) CMC
d) Tetracycline
Explanation: PVP is a binding agent. Carbowaxes is a soluble lubricant. CMC is an example of semisynthetic gums. And Tetracycline is diluent.