1. The deleterious effect of various coatings on drug dissolution is shown in orders below. Which one of them is the correct order?
a) Enteric coat > sugar coat > nonenteric film coat
b) Enteric coat > nonenteric film coat > sugar coat
c) Nonenteric film coat > sugar coat > enteric coat
d) Sugar coat > enteric coat > nonenteric film coat
Explanation: The deleterious effect of various coatings on drug dissolution rate is in the following order enteric coat > sugar coat > nonenteric film coat. The dissolution rate of some coatings changes while they age e.g. shellac coated tablet
2. Which of the following will be an example of an organic suspending agent?
a) CMC
b) MC
c) Acacia
d) Carbowaxes
Explanation: CMC and MC are examples of semisynthetic gums. Acacia is an example of a vegetable drug that is organic. Carbowaxes is an example of a soluble lubricants.
3. Which one of these is not a mechanism of the working of surfactants?
a) Promote wetting by increasing the effective surface area
b) Helps in the dissolution of drug
c) Better membrane contact of the drug
d) Decrease membrane permeability
Explanation: Mechanism involved in the increased absorption of the drug is, promotion of wetting through the increased surface area. These also help in better membrane contact and enhanced membrane permeability
4. PABA complex is used for the enhancement of ______________
a) Enhanced chelation
b) Enhanced dissolution
c) Enhanced membrane permeability
d) Enhanced lipophilicity
Explanation: Complexing agents are used to altering the physiochemical and biopharmaceutical properties of drugs. PABA complex is used to enhance lipophilicity for better membrane permeability.
5. The concentration of colorant does not affect the drug solubility.
a) True
b) False
Explanation: Low concentration water soluble dye have inhibitory effect on the dissolution Rte OF SEVERAL crystalline drugs. The dye molecules get adsorbed on the crystal faces and inhibit drug dissolution
6. Suspending agents and some sugars can be used as viscosity imparters.
a) True
b) False
Explanation: Suspending agents and some of the sugars can be used to increase the viscosity of the drug. This affects the palatability and the pourability of the solution dosage form. This influence drug absorption ways.
7. Which of the following will be the slowest step in tablet drug absorption?
a) Tablet disintegration to granules
b) Granules disintegration to fine particles
c) Fine particles dissolution
d) Dissolution absorbed into the blood
Explanation: The rate at which drug will be getting absorbed from the drug from the blood depends upon the drug formulation. In the case of a tablet, the disintegration of the tablet into smaller particles will be the slowest step
8. Aging of dosage form affects drug release.
a) True
b) False
Explanation: Aging of drugs affects drug release. It happens mostly with shellac coated drugs. Experiments showed that shellac coated tablets stored for 2 years have a 60% decrease in their plasma level.
9. Which form of the drug has the highest bioavailability?
a) Coated tablets
b) Solutions
c) Tablets
d) Emulsions
Explanation: Solutions are readily available. Thus having the highest bioavailability. Tablets take time to disintegrate. The order of decreasing bioavailability will be, solutions > emulsions > suspensions > capsules > tablets > coated tablets > enteric coated tablets>sustained released products.
10. Why emulsion dosage form for lipophilic drugs proved better?
a) Easy manufacturing
b) The higher stability of the drug in emulsion form
c) Presented a large surface area of oil to the GIT for the absorption of the drug
d) Fast clearance from the plasma
Explanation: Emulsion dosage form is superior to suspensions in administering the lipophilic drug into the body. This is because the emulsion dosage form provides a large surface area of oil to the GIT for the absorption of the drug.