1. Which drugs deposit in hair shafts?
a) Arsenicals
b) Tetracycline
c) Halogenated hydrocarbons
d) Lipophilic drug
Explanation: Arsenicals, chloroquine, phenothiazines are reported to deposit in hair shaft. Tetracycline binds to bones and teeths. Lipophilic drugs accumulate in adipose tissues. Epoxides of number of Halogenated hydrocarbon and paracetamol bind irreversibly to the liver tissues resulting in hepatotoxicity.
2. Which drug causes brown yellow discoloration of infant’s teeth?
a) Arsenicals
b) Tetracycline
c) Halogenated hydrocarbons
d) Lipophilic drug
Explanation: Tetracycline, this drug tends to bind to bones and teeth. Administration of this antibiotic to infants or children during odontogenesis results in permanent brown yellow colour discoloration of teeth.
3. Which drug accumulate in adipose tissue?
a) Arsenicals
b) Tetracycline
c) Halogenated hydrocarbons
d) Lipophilic drug
Explanation: Lipophilic drugs such as that of thiopental and pesticides such as DDT accumulate in adipose tissue. Halogenated hydrocarbon and paracetamol bind irreversibly to the liver tissues resulting in hepatotoxicity. Tetracycline tends to bind to bones and teeth.
4. Which drugs results in distortion of double stranded DNA structure?
a) Arsenicals
b) Quinacrine
c) Halogenated hydrocarbons
d) Lipophilic drug
Explanation: DNA interacts with drugs like Chloroquine and Quinacrine. These drugs result in distortion of the double stranded helical structure of the DNA
5. Which one of the following factors related to protein-drug binding is not related to drugs?
a) Physicochemical characteristics of a drug
b) The concentration of the drug in the body
c) The affinity of the drug for binding
d) Number of binding sites on the binding agent
Explanation: There are many factors affecting protein-drug binding. The factors related to the drug, are physicochemical characteristics of a drug, concentration of the drug in the body, affinity of the drug for binding. A number of binding sites on the binding agent are related to the protein and other binding components
6. Which one of the following factor related to protein-drug binding is not related to drug interactions with the binding site?
a) Competition between the drug and the binding site
b) Competition between drugs and normal body constituents
c) Allosteric changes in a protein molecule
d) Inter subject variation
Explanation: Competition between the drug and the binding site, competition between drugs and normal body constituents, allosteric changes in protein molecule these factors are related to drug interactions. Inter subject variation is a patient-related factor.
7. Which of the following factors for protein drug binding is a drug interaction factor?
a) Competition between drugs for the binding site
b) Age
c) Physicochemical characteristics of a drug
d) Physicochemical characteristics of the protein or binding agent
Explanation: Physicochemical interaction is not a drug interaction factor. Competition between the drug and the binding site and competition between drug and other normal body constituents, allosteric changes in protein molecule all these factors are related to drug interaction with the protein. Age is a patient-related factor.
8. Which drugs bind to HSA easily?
a) Cationic drug
b) Anionic drug
c) Lipophilic drug
d) Neutral drug
Explanation: Anionic or acidic drugs bind to HSA easily, for example, penicillin and sulphonamides. Cationic or basic drugs bind easily to alpha 1 acid glycoprotein, for example, imipramine and alprenolol. Neutral and unionized drugs bind to lipoproteins. Lipophilic drugs localize more into adipose tissue.
9. Which drugs easily bind to adipose tissue?
a) Cationic drug
b) Anionic drug
c) Lipophilic drug
d) Neutral drug
Explanation: Anionic or acidic drugs bind to HSA easily. Cationic or basic drugs bind easily to alpha 1 acid glycoprotein. Neutral and unionized drugs bind to lipoproteins. Lipophilic drugs localize more into adipose tissue. Since lipophilic drugs are lipid loving they can easily get deposited on the adipose tissue
10. Which drug easily bind to AAG?
a) Cationic drug
b) Anionic drug
c) Lipophilic drug
d) Neutral drug
Explanation: Anionic or acidic drugs bind to HSA easily. Cationic or basic drugs having negative charge can bind easily to alpha 1 acid glycoprotein, for example, imipramine and alprenolol. Neutral and unionized drugs bind to lipoproteins. Lipophilic drugs localize more into adipose tissue