1. Ibuprofen a weak acid, in the stomach will be present in which of the given form?
a) Ionized form mostly
b) Non-ionized form mostly
c) Half ionized and half no ionized
d) Will form aggregate
Explanation: The pH of the stomach is 1.5. Ibuprofen being a weak acid will be in a unionized form in the stomach. At pH 7.4 in plasma, it will be in ionized form and in the same format pH 5 in the intestine
2. Nitrazepam a weak base, will be in which form in the stomach?
a) Ionized form mostly
b) Non-ionized form mostly
c) Half ionized and half no ionized
d) Will form aggregate
Explanation: The pH of the stomach is 1.5. Nitrazepam being a weak base will be in an ionized form in the stomach. In plasma and small intestine with pH 7.4 and 5 respectively, Nitrazepam will be in unionized form.
3. All drugs which are weak acids or acidic in nature will be in a unionized form in the plasma.
a) True
b) False
Explanation: Acidic or weak acidic drugs are always present in their ionized form in a basic or neutral environment. In plasma and small intestine with pH 7.4 and 5 respectively, rendering all acidic drug be present in their ionized form
4.Heroin with pKa 7.8 will be in which form in intestinal pH?
a) Ionized form mostly
b) Unionized form mostly
c) Half ionized and half no ionized
d) Will form aggregate
Explanation: Drugs that are moderately weak bases with pKa 5-11 will get ionized at gastric pH, stay unionized at intestinal pH and get absorbed through the intestinal wall. Thus, heroin being a weak base will stay at unionized condition in the intestinal pH. It will not form any aggregate.
5. Which form of drug formulation has disintegration time?
a) Injections
b) Syrups
c) Capsules and Tablets
d) Only tablets
Explanation: Disintegration time is of importance in the case of solid dosage forms like tablets and capsules. Disintegration time is the time taken by the capsule to disintegrate into smaller particles.
6. Which tablets have longer Disintegration time?
a) Single coated tablets
b) Uncoated tablets
c) Sugar-coated tablets
d) Capsules
Explanation: Disintegration time is the time taken by the capsule to disintegrate into smaller particles. Enteric coated tablets are coated to protect the drug from the acidic environment of the stomach. Sugar coated ones have long DT
7. Disintegration time is directly proportional to the amount of binder present in the tablet.
a) True
b) False
Explanation: Disintegration of a tablet is directly proportional to the amount of binder present and the compression force i.e. the hardness of the tablet. A hard tablet with a large amount of binder has a long DT.
8. Which of the following is not a form of excipients?
a) Paracetamol
b) Disintegrants
c) Lubricants
d) Binders
Explanation: Paracetamol is a drug name. It is the active ingredient. Excipients are all the other additional materials that help in drug formulation e.g. binders, lubricants, disintegrants, buffer, etc.
9. Which of the following is not a limitation granulation?
a) Formation of crystal bridge by the presence of liquid
b) The liquid may act as a medium for affecting chemical reactions such as hydrolysis
c) Increase the cost due to more additional processing
d) The drying step may harm the thermolabile drugs
Explanation: limitation of wet granulation method is Formation of Crystal Bridge by the presence of liquid, the liquid may act as a medium for affecting chemical reactions such as hydrolysis, and the drying step may harm the thermolabile drugs.
10. The agglomerative phase of the communication method grinds the drug in a ball mill for a long time to affect spontaneous agglomeration. But results showed tablets produced are softer.
a) True
b) False
Explanation: Agglomerative phase of communication is a recent process which involves grinding the drug in a ball mill for a long time to affect spontaneous agglomeration. The tablets so produced were stronger and showed rapid dissolution in comparison to tablets made by other methods