1. Which is the major rate-limiting step in the absorption of a drug from suspension dosage?
a) Tablet disintegration to granules
b) Granules disintegration to fine particles
c) Fine particles dissolution
d) Dissolution absorbed into the blood
Explanation: The step of drug dissolution is generally rapid due to the large surface area of the particles. Factors which are essential in drug dissolution from the suspension are particle size, polymorphism, wettability, etc.
2. Which coating is thin and dissolve rapidly?
a) Sugar coating
b) Film coating
c) Enteric coating
d) Sealing coating
Explanation: Film coating is thin and dissolves rapidly and thus don’t affect drug absorption. Sugar coat is tough and takes a longer time than film coating to dissolve.
3. Which option describes the function of the enteric coated drug?
a) Tough dissolves slowly
b) Thin dissolves completely
c) Dissolves only in alkaline pH of the intestine
d) Shellac coating
Explanation: The enteric coated tablet only dissolves in the alkaline environment of the intestine. It may take 2-4hrs for the enteric coated tablet to empty form the stomach to the intestine.
4. Hydrophobic drug with fine particle size in capsule results in a decreasing porosity of powder bed.
a) True
b) False
Explanation: Hydrophobic drug with fine particle size in capsule results in a decreasing porosity of the powder to the fluids outside. Thus it decreases the penetrability of the solvent into the powder. This results in clumping of the particles.
5. Viscous fluids and oils are administered in hard gelatin capsules.
a) True
b) False
Explanation: Powders and granules are administered in hard gelatin capsules. And viscous fluids and oils are administered in soft elastic shells
6. From the below options which will be the most widely used form of dosage?
a) Emulsion
b) Solutions
c) Tablets
d) Powders
Explanation: Tablets are the most widely used dosage form. Because of their convenience of usage, cost-effective. Powders are less used because of a quantity of dosage is the major problem. Solutions and suspension, storage and shelf life is a major problem
7. What is the mean length of GIT?
a) 350 cm
b) 200cm
c) 400cm
d) 450cm
Explanation: The mean length of Git tract is 450 cm. The gastrointestinal tract comprises of a number of components whose primary function is secretion, digestion, and absorption
8. The entire length of the GI is lined by ___________
a) Blood vessels
b) Nerves
c) Mucopolysaccharides
d) No lining direct contact with the cell
Explanation: The entire GI tract is lined by mucus or mucopolysaccharides. It acts as an impermeable barrier to the particles such as that of bacteria, cells or food particles protecting our body from harmful organisms
9. Which drugs get absorbed in the stomach mostly?
a) Basic drugs
b) Acidic Drugs
c) Neutral drugs
d) No drug gets absorbed in the stomach
Explanation: Due to the acidic pH of the stomach, which is due to the secretion of HCL into the stomach, only acidic drug absorption is favoured. But this is possible only if the drugs are soluble in the gastric fluids because most of the drugs get unionized because of the lower pH
10. Which drugs gets mostly absorbed from the mouth?
a) Acidic drugs and lipophilic drugs
b) Lipophilic drugs and neutral drugs
c) Neutral drugs and lipophilic drugs
d) Lipophilic, neutral, basic drugs
Explanation: The pH of the mouth is 6.8. So no acidic drug can get absorbed through the lining of our mouth. Only lipophilic drugs, neutral drugs, and basic drugs get absorbed into the systemic circulation.