1. Which is the other name of “cell eating”?
a) Transcytosis
b) Phagocytosis
c) Pinocytosis
d) Endocytosis
Explanation: Phagocytosis is a type of endocytosis. Phagocytosis is also called cell eating which includes absorption of solid particulates. Endocytosis is of two types phagocytosis and pinocytosis later meaning cell drinking
2. Transfer of an endocytic vesicle from one extracellular compartment to another is known as _____________
a) Phagocytosis
b) Transcytosis
c) Pinocytosis
d) Endocytosis
Explanation: Transfer of an endocytic vesicle from one extracellular compartment to another is known as Transcytosis. Phagocytosis is the engulfing of solid particulates. Pinocytosis is the absorption of fluids.
3. A drug can be absorbed by more than one mechanism.
a) True
b) False
Explanation: Yes, a drug can be absorbed by different mechanisms through different sites in the body. The mechanism depends upon the absorption site of the body. A drug can be absorbed passively and actively
4. Which one of these is a physicochemical property of Drug substance?
a) Drug solubility
b) Disintegration time
c) Age of patient
d) Dissolution time
Explanation: Pharmaceutical factors include factors relating to the physicochemical properties of the drug and dosage. The physicochemical property includes drug solubility, dissolution rate, particle size, etc.
5. Which one of these does not come under a physicochemical property of drugs?
a) Drug solubility
b) Disintegration time
c) Dissolution rate
d) Drug stability
Explanation: Physicochemical properties of drug substances include drug solubility, dissolution rate, particle size, effective surface area, polymorphism, etc. Dissolution time comes under Dosage form characteristics and pharmaceutic ingredients
6. In the sequence of events in the drug absorption from orally administered solid dosage, which one comes at first?
a) Disintegration
b) Disaggregation
c) Dissolution
d) Absorption
Explanation: The solid dosage form at first disintegrate into smaller granules or aggregates. Those are then deaggregated to form fine particles. In dissolution, the drug is in the solution form and then it gets absorbed.
7. Which one is the correct sequence for drug absorption through the oral route?
a) Absorption – Dissolution – Disintegration – Deaggregation
b) Disintegration – Dissolution – Deaggregation – Absorption
c) Disintegration – Deaggregation – Dissolution – Absorption
d) Disintegration – Deaggregation – Absorption – Dissolution
Explanation: Disintegration of the drug and then Deaggregation and subsequent release of a drug. Followed by the dissolution of the drug in aqueous fluids at the absorption site and the movement of the dissolved drug through the gastrointestinal membrane into the systemic circulation.
8. Patient-related factors of drug absorption do not deal with which one of these?
a) Age
b) Gastric Emptying time
c) Intestinal transit time
d) Pharmaceutic ingredients
Explanation: Patient-related factors include factors related to anatomy, physiology, and pathologic characteristic of a patient. This includes age, Gastric Emptying time, Intestinal transit time, gastrointestinal pH, Disease states, Blood flow, etc.
9. The rate at which drug reaches the systemic circulation is determined by the slowest of the various steps involved in the sequence. This is known as ____________
a) Disintegration time
b) Dissolution time
c) Rate limiting step
d) Gastric Emptying time
Explanation: The rate at which drug reaches the systemic circulation is determined by the slowest of the various steps involved in the sequence. Such a step is known as the rate-limiting. Disintegration time is the time required for the drug to be broken down into smaller particles or aggregates. Dissolution time is the time required for all the drug disintegrated particle to dissolve in the fluid. Gastric emptying time is the emptying time of the stomach.
10. Diffusion coefficient of drug D, Greater the value faster us the dissolution.
a) True
b) False
Explanation: Greater the value faster is the dissolution of the drug into solution. Diffusion decreases as the viscosity of the dissolution medium increase.