1. Monitoring of blood levels of diuretic drugs is not
practised because:
a) No sensitive methods for measuring blood levels
of diuretics are available
b) It is easier to measure the effect of these drugs
c) Response to diuretics is not related to their
blood levels
d) Diuretics need activation in the body
2. Monitoring plasma drug concentration is useful while
using:
a) Antihypertensive drugs
b) Levodopa
c) Lithium carbonate
d) MAO inhibitors
3. Sustained/controlled release oral dosage form is
appropriate for the following type of drug:
a) An antiarthritic with a plasma half life of 24 hr
b) A sleep inducing hypnotic with a plasma half life
of 2 hours
c) An antihypertensive with a plasma half life of 3
hours
d) An analgesic with a plasma half life of 6 hours
used for relief of casual headache
4. Microsomal enzyme induction has one of the following
features:
a) Takes about one week to developr
b) Results in increased affinity of the enzyme for
the substrate
c) It is irreversible
d) Can be used to treat acute drug poisonings
5. Which of the following drugs acts by inhibiting an
enzyme in the body
a) Atropine
b) Allopurinol
c) Levodopa
d) Metoclopramide
6. The following is a competitive type of enzyme inhibitor:
a) Acetazolamide
b) Disulfiram
c) Physostigmine
d) Theophylline
7. What is true in relation to drug receptors:
a) All drugs act through specific receptors
b) All drug receptors are located on the surface of
the target cells
c) Agonists induce a conformational change in
the receptor
d) Partial agonists have low affinity for the
receptor
8. Drugs acting through receptors exhibit the following
features except:
a) Structural specificity
b) High potency
c) Competitive antagonism
d) Dependence of action on lipophilicity
9. Study of drug-receptor interaction has now shown that
a) Maximal response occurs only when all receptors are occupied by the dru
b) Drugs exert an ‘all or none’ action on a recepto
c) Receptor and drugs acting on it have rigid
complementary ‘lock and key’ structural features
d) Properties of ‘affinity’ and ‘intrinsic activity’ are
independently variable
10. A partial agonist can antagonise the effects of a full
agonist because it has:
a) High affinity but low intrinsic activity
b) Low affinity but high intrinsic activity
c) No affinity and low intrinsic activity
d) High affinity but no intrinsic activity