1. A drug which is generally administered in standard
doses without the need for dose individualization is:
a) Insulin
b) Mebendazole
c) Prednisolone
d) Digoxin
2. Which of the following statements is not true of fixed
dose combination formulations:
a) They are more convenient
b) Contraindication to one of the components does
not contraindicate the formulation
c) The dose of any one component cannot be
independently adjusted
d) The time course of action of the different components may not be identical
3. Fixed dose combination formulations are not necessarily
appropriate for:
a) Drugs administered in standard doses
b) Drugs acting by the same mechanism
c) Antitubercular drugs
d) Antihypertensive drugs
4. A fixed dose combination preparation meant for internal
use must not contain the following class of drug:
a) Thiazide diuretic
b) Fluoroquinolone antimicrobial
c) Corticosteroid
d) H2 blocker
5. Interindividual variations in equieffective doses of a
drug are most marked if it is disposed by:
a) Glomerular filtration
b) Tubular secretion
c) Both glomerular filtration and tubular secretion
d) Hepatic metabolism
6. The pharmacokinetics of drugs in the neonate differs
from that in adults, because their:
a) Intestinal transit is fast
b) Drug metabolizing enzymes are overactive
c) Tubular transport mechanisms are not well
developed
d) Glomerular filtration rate is high
7. Which adverse drug effect is more common in children
than in adults:
a) Isoniazid induced neuropathy
b) Chlorpromazine induced muscle dystonia
c) Digoxin induced cardiac arrhythmia
d) Penicillin hypersensitivity
8. The elderly patients are relatively intolerant to
a) Digoxin
b) Salbutamol
c) Propranolol
d) Nifedipine
9. The following drug adverse effect is specially noted in
men compared to women:
a) Tardive dyskinesia due to neuroleptics
b) Levodopa induced abnormal movements
c) Ampicillin induced loose motions
d) Ketoconazole induced loss of libido
10. Which racial difference in response to drugs has been
mentioned incorrectly below:
a) Africans require higher concentration of atropine to dilate pupils
b) Black races are more responsive to antihypertensive action o
c) Japanese are more prone to develop SMON due
to halogenated hydroxyquinolines
d) Chloramphenicol induced aplastic anaemia is
rare among Indians