1. `Diffusion of drugs across cell membrane:
a) Is dependent upon metabolic activity of the cell
b) Is competitively inhibited by chemically
related drugs
c) Is affected by extent of ionization of drug molecules
d) Exhibits saturation kinetics
2. Which of the following drugs is most likely to be
absorbed from the stomach:
a) Morphine sulfate
b) Diclofenac sodium
c) Hyoscine hydrobromide
d) Quinine dihydrochloride
3. Which of the following is a weakly acidic drug:
a) Atropine sulfate
b) Chloroquine phosphate
c) Ephedrine hydrochloride
d) Phenytoin sodium
4. The most important factor which governs diffusion of
drugs across capillaries other than those in the brain is:
a) Blood flow through the capillary
b) Lipid solubility of the drug
c) pKa value of the drug
d) pH of the medium
5. Active transport of a substance across biological
membranes has the following characteristics except:
a) It is specific
b) It is pH dependent
c) It is saturable
d) It requires metabolic energy
6. Tricyclic antidepressants can alter the oral absorption
of many drugs by:
a) Complexing with the other drug in the intestinal lume
b) Altering gut motility
c) Altering gut flora
d) Damaging gut mucosa
7. Bioavailability of drug refers to:
a) Percentage of administered dose that reaches
systemic circulation in the unchanged form
b) Ratio of oral to parenteral dose
c) Ratio of orally administered drug to that excreted in the f
d) Ratio of drug excreted unchanged in urine to
that excreted as metabolites
8. Bioavailability differences among oral formulations of
a drug are most likely to occur if the drug:?
a) Is freely water soluble
b) Is completely absorbed
c) Is incompletely absorbed
d) Undergoes little first-pass metabolism
9. The most important factor governing absorption of a
drug from intact skin is:
a) Molecular weight of the drug
b) Site of application
c) Lipid solubility of the drug
d) Nature of the base used in the formulation
10. If the total amount of a drug present in the body at a
given moment is 2.0 g and its plasma concentration is
25 μg/ml, its volume of distribution is:
a) 100 L
b) 80 L
c) 60 L
d) 50 L