1. Receptor agonists possess
a) Affinity but no intrinsic activity
b) Intrinsic activity but no affinity
c) Affinity and intrinsic activity with a + sign
d) Affinity and intrinsic activity with a – sign
2. Agonists affect the receptor molecule in the following
manner:
a) Alter its amino acid sequence
b) Denature the receptor protein
c) Alter its folding or alignment of subunits
d) Induce covalent bond formation
3. Receptors perform the following function/functions:
a) Ligand recognition
b) Signal transduction
c) Both ligand recognition and signal transduction
d) Disposal of agonists and antagonists
4. The following receptor type has 7 helical membrane
spanning amino acid segments with 3 extracellular
and 3 intracellular loops:
a) Tyrosine protein kinase receptor
b) Gene expression regulating receptor
c) Intrinsic ion channel containing receptor
d) G protein coupled receptor
5. Which of the following is a G protein coupled recepto
a) Muscarinic cholinergic receptor
b) Nicotinic cholinergic receptor
c) Glucocorticoid receptor
d) Insulin receptor
6. The following receptor has an intrinsic ion channel
a) Histamine H1 receptor
b) Histamine H2 receptor
c) Adrenergic alfa receptor
d) GABA-benzodiazepine receptor
7. Select the receptor that is located intracellularly
a) Opioid μ receptor
b) Steroid receptor
c) Prostaglandin receptor
d) Angiotensin receptor
8. Agonist induced autophosphorylation, internalization
and down regulation is a distinctive feature of:
a) G-protein coupled receptors
b) Intrinsic ion channel containing receptors
c) Tyrosine protein kinase receptors
d) Receptors regulating gene expression
9. All of the following subserve as intracellular second
messengers in receptor mediated signal transduction
except:
a) Cyclic AMP
b) Inositol trisphosphate
c) Diacyl glycerols
d) G proteins
10. The receptor transduction mechanism with the fastest
time-course of response effectuation is
a) Adenylyl cyclase-cyclic AMP pathway
b) Phospholipase C-IP3: DAG pathway
c) Intrinsic ion channel operation
d) Protein synthesis modulation