1. The therapeutic index of a drug is a measure of its:
a) Safety
b) Potency
c) Efficacy
d) Dose variability
2. Compared to the drug named within parenthesis, which
of the following drugs has a higher potency but lower
efficacy
a) Pethidine (morphine)
b) Furosemide (hydrochlorothiazide)
c) Diazepam (pentobarbitone)
d) Enalapril (captopril)
3. if the effect of combination of two drugs is equal to
the sum of their individual effects, the two drugs are
exhibiting:
a) Potentiation
b) Synergism
c) Cross tolerance
d) Antagonism
4. The antagonism between adrenaline and histamine is
called ‘physiological antagonism’ because:
a) Both are physiologically present in the body
b) They act on physiological receptors
c) Both affect many physiological processes
d) They have opposite physiological effects
5. The antidotal action of sodium nitrite in cyanide poisoning is based
a) Physical antagonism
b) Chemical antagonism
c) Physiological antagonism
d) Noncompetitive antagonism
6. A drug ‘R’ producing no response by itself causes the
log dose-response curve of another drug ‘S’ to shift to
the right in a parallel manner without decreasing the
maximal response: Drug ‘R’ is a:
a) Partial agonist
b) Inverse agonist
c) Competitive antagonist
d) Noncompetitive antagonist
7. A drug which does not produce any action by itself but
decreases the slope of the log dose-response curve and
suppresses the maximal response to another drug is a:
a) Physiological antagonist
b) Competitive antagonist
c) Noncompetitive antagonist
d) Partial agonist
8. The following is not a feature of competitive antagonists
a) Chemical resemblance with the agonist
b) Parallel rightward shift of the agonist log doseresponse curve
c) Suppression of maximal agonist response
d) Apparent reduction in agonist affinity for the
receptor
9. The following is a competitive antagonist of GABA but
a noncompetitive antagonist of diazepam:
a) Picrotoxin
b) Muscimol
c) Flumazeni
d) Bicuculline
10. The dose of the following class of drugs has to be
adjusted by repeated measurement of the affected
physiological parameter:
a) Oral contraceptives
b) Antiepileptics
c) Antidepressants
d) Oral anticoagulants