1. A prodrug is:
a) The prototype member of a class of drugs
b) The oldest member of a class of drugs
c) An inactive drug that is transformed in the
body to an active metabolite
d) A drug that is stored in body tissues and is then
gradually released in the circulation
2. Which of the following cytochrome P450 isoenzymes
is involved in the metabolism of largest number of
drugs in human beings and has been implicated in
some dangerous drug interactions:
a) CYP 3A4
b) CYP 2C9
c) CYP 2E1
d) CYP 1A2
3. The following is not true of the cytochrome P450
isoenzyme CYP2D6:
a) It generates the hepatotoxic metabolite N-acetyl
benzoquinone immine from paracetamol
b) It is involved in demethylation of codeine into
morphine
c) Its altered form is responsible for poor capacity to
hydroxylate many drugs including metoprolol
d) It is inhibited by quinidine
4. The most commonly occurring conjugation reaction for
drugs and their metabolites is:
a) Glucuronidation
b) Acetylation
c) Methylation
d) Glutathione conjugation
5. Microsomal enzyme induction can be a cause of:
a) Tolerance
b) Physical dependence
c) Psychological dependence
d) Idiosyncrasy
6. The following drug metabolizing reaction is entirely
nonmicrosomal:
a) Glucuronide conjugation
b) Acetylation
c) Oxidation
d) Reduction
7. Which of the following types of drug metabolizing
enzymes are inducible:
a) Microsomal enzymes
b) Nonmicrosomal enzymes
c) Both microsomal and nonmicrosomal enzymes
d) Mitochondrial enzymes
8. Induction of drug metabolizing enzymes involves:
a) A conformational change in the enzyme protein
to favour binding of substrate molecules
b) Expression of enzyme molecules on the
surface of hepatocytes
c) Enhanced transport of substrate molecules
into hepatocytes
d) Increased synthesis of enzyme protein
9. Select the drug that undergoes extensive first-pass
metabolism in the liver:
a) Phenobarbitone
b) Propranolol
c) Phenylbutazone
d) Theophylline
10. Drugs which undergo high degree of first-pass metabolism in
a) Have low oral bioavailability
b) Are excreted primarily in bile
c) Are contraindicated in liver disease
d) Exhibit zero order kinetics of elimination