1. A receptor which itself has enzymatic property is
a) Insulin receptor
b) Progesterone receptor
c) Thyroxine receptor
d) Glucagon recepto
2. Down regulation of receptors can occur as a
consequence of:
a) Continuous use of agonists
b) Continuous use of antagonists
c) Chronic use of CNS depressants
d) Denervation
3. The following statement is not true of log dose-response
curve:
a) It is almost linear except at the ends
b) It is a rectangular hyperbola
c) It facilitates comparison of different agonists
d) It can help in discriminating between competitive
and noncompetitive antagonists
4. When therapeutic effects decline both below and above
a narrow range of doses, a drug is said to exhibit
a) Ceiling effect
b) Desensitization
c) Therapeutic window phenomenon
d) Nonreceptor mediated action
5. Which of the following drugs exhibits ‘therapeutic
window’ phenomenon:
a) Captopril
b) Furosemide
c) Diazepam
d) Imipramine
6. The following statement is not true of ‘potency’ of a
drug:
a) Refers to the dose of the drug needed to produce
a certain degree of response
b) Can be related to that of its congeners by the
relative position of its dose-response curve on
the dose axis
c) It is often not a major consideration in the
choice of a drug
d) It reflects the capacity of the drug to produce
a drastic response
7. ‘Drug efficacy’ refers to:
a) The range of diseases in which the drug is
beneficial
b) The maximal intensity of response that can
be produced by the drug
c) The dose of the drug needed to produce half
maximal effect
d) The dose of the drug needed to produce theraeutic effect
8. Which of the following is always true
a) A more potent drug is more efficacious
b) A more potent drug is safer
c) A more potent drug is clinically superior
d) A more potent drug can produce the same
response at lower doses
9. Higher efficacy of a drug necessarily confers:
a) Greater safety
b) Therapeutic superiority
c) Capacity to produce more intense response
d) Cost saving
10. If the dose-response curves of a drug for producing
different actions are widely separated on the dose
axis, the drug is:
a) Highly potent
b) Highly efficacious
c) Highly toxic
d) Highly selective