1. `The following attribute of a drug tends to reduce its
volume of distribution:
a) High lipid solubility
b) Low ionisation at physiological pH values
c) High plasma protein binding
d) High tissue binding
2. Marked redistribution is a feature of
a) Highly lipid soluble drugs
b) Poorly lipid soluble drugs
c) Depot preparations
d) Highly plasma protein bound drugs
3. A nonvolatile, highly lipid soluble drug is metabolized
at a rate of 15% per hour. On intravenous injection it
produces general anaesthesia for 10 min. Which process is responsible for termination of its action
a) Metabolism in liver
b) Plasma protein binding
c) Excretion by kidney
d) Redistribution
4. The blood-brain barrier, which restricts entry of many
drugs into brain, is constituted by:
a) P-glycoprotein efflux carriers in brain
capillary cells
b) Tight junctions between endothelial cells of
brain capillaries
c) Enzymes present in brain capillary walls
d) All of the above
5. Which of the following is not true of the blood-brain
barrier:
a) It is constituted by tight junctions between
the endothelial cells of brain capillaries and
the glial tissue
b) It allows passage of lipid soluble drugs into
the brain
c) It limits entry of highly ionized drugs into the brain
d) It regulates passage of substances from brain
into blood
6. Weakly acidic drugs:
a) Are bound primarily to α1 acid glycoprotein in
plasma
b) Are excreted faster in alkaline urine
c) Are highly ionized in the gastric juice
d) Do not cross blood-brain barrier
7. High plasma protein binding:
a) Increases volume of distribution of the drug
b) Facilitates glomerular filtration of the drug
c) Minimises drug interactions
d) Generally makes the drug long acting
8. The plasma protein bound fraction of a drug:
a) Contributes to the response at the given moment
b) Remains constant irrespective of the total drug
concentration
c) Remains constant irrespective of the disease state
d) Is not available for metabolism unless actively
extracted by the liver
9. Biotransformation of drugs is primarily directed to:
a) Activate the drug
b) Inactivate the drug
c) Convert lipid soluble drugs into nonlipid soluble metabolites
d) Convert nonlipid soluble drugs into lipid soluble metabol
10. Which of the following is a prodrug
a) Hydralazine
b) Clonidine
c) Captopril
d) Enalapril